System One BiPAP PRO 650 Machine with Bi-Flex (DISCONTINUED)

Philips Respironics System One BiPAP PRO 650 Machine with Bi-Flex (DISCONTINUED)

5.00 Average Rating of 8 Reviews Read Reviews

Discontinued Item:

For Reference: Discontinued January 2016


The System One BiPAP PRO includes all of the great features you expect from a sleep therapy system including a wide pressure range (4-25cm), patient adjustable ramp, AUTOMATIC altitude adjustment, data card, the latest BiFlex comfort technologies, and a universal power supply. In addition the BiPAP PRO provides bi-level therapy -- with a high pressure on inhalation and low pressure on expiration -- to provide a more comfortable sleep experience than standard CPAP therapy. Finally the BiPAP PRO features resistance control technologies that adjust to different mask styles, and advanced therapy tracking capabilities -- including advanced event detection and reporting.

Respironics natural and clinically-proven "flex" technologies enhance traditional pressure therapy to improve comfort and increase compliance. Bi-Flex, on the BiPAP PRO, offers pressure relief at inhalation and exhalation to make BiPAP therapy more like natural breathing. By tracking each breath, Bi-Flex pressure relief technology always delivers pressure relief just when it is needed for an improved sleep experience.

Many BiPAP users find that the addition of heated humidity to their sleep therapy system improves comfort and helps with overall compliance. The optional System One Heated Humidifier delivers optimum humidity, drastically reduces rainout, and provides ultimate comfort throughout the night by analyzing and adjusting to ambient temperature, changing environmental conditions, relative humidity, and therapy flow. Revolutionary Dry Box technology isolates the humidfier's water source from the inner workings of the device to protect against accidental spillage and water damage.

System One Resistance Control achieves complete system comfort by enabling the device and mask to work optimally together. Through simple settings, the System One Resistance Control instructs your BiPAP to compensate for variable resistance characteristics related to different masks. The result is synchronous pressure delivery and the assurance you can enjoy the full benefits of Respironics Flex comfort technologies no matter which mask is used.

The System One BiPAP PRO tracks many common OSA related events including Hypopneas, Flow Limitation, Respiratory Effort Related Arousal, Snores, and Leaks. In addition the BiPAP PRO can detect many symptoms beyond classic OSA -- such as clear airway apneas, obstructed airway apneas, and periodic breathing -- that may indicate the need for specialized therapy.

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Product Information

  • Manufacturer Philips Respironics
  • In the Package PR System One BiPAP Pro 650 BiLevel with Heated Humidifier, SD Data Card, Carrying Case, Filters (2 Reusable Foam Filters Included, Optional Ultra Fine Filters Available Separately), 6-Foot Performance Tubing, Printed Users Manual, Power Cord & External AC Power Supply, 2-Year Manufacturer's Warranty (BiPAP Only).
  • Part Number(s) DS650S (BiPAP), DS650HS (BiPAP with Heated Humidifier)
  • HCPCS Code E0470
  • GTIN / UPC Code
  • Warranty 2 Years
    Warranty Notes: Warranty applies to primary item. Accessory and parts warranties may vary. Review manufacturer's documentation for full details.
  • Prescription Item Prescription required for the purchase of this item.
  • Country United States of America (Typical Origin)

Physical Specifications

  • Size (Approx) BiPAP = 7 in x 5.5 in x 4 in BiPAP with Humidifier = 7 in x 10.75 in x 4 in Power Supply = 4.5 in x 2.5 in x 1.75 in
  • Weight (Approx) BiPAP = 3 lbs BiPAP with Humidifier = 4.8 lbs Power Supply = .75 lbs

Performance Specifications

  • Therapy Modes CPAP, BiPAP
  • Pressure Range 4-25 CM H2O
  • Ramp 0 to 45 Minutes (5 Minute Increments)
  • Ramp Start 4 to EPAP Pressure (User adjustable)
  • Sound Levels Average less than 30 dBA @ 10cm H2O
  • Altitude Adjustment Automatic up to 9000 Feet
  • Leak Compenstation Automatic
  • Auto On/Off Yes
  • Comfort Technology Bi-Flex


  • Masks Compatible with all CPAP/BiPAP Masks
  • Tubing Compatible with all Standard CPAP Tubing, Performance Tubing, and Slim Performance Tubing.
  • Humidifiers SystemOne Integrated Humidifier (Optional)

Therapy Data & Compliance

  • Data Storage More Than 1 Year of Data... Hours of Use, Visual Inspection Compliance, Apnea Hypopnea Index, Flow Limitation, Respiratory Effort Related Arousal, Snore, Leak, Clear Airway Apnea, Obstructed Airway Apnea, Hypopnea, Periodic Breathing
  • Data Viewing Compliance Visual Inspection Compliance, 7 and 30-day averages

Humidifier Specifications

  • Humidifier SystemOne Integrated Humidifier (Optional)
  • Chamber Capacity 1 1/3 cups (325ml) at Recommended Water Level
  • Humidifier Power Direct Power via CPAP/BiPAP Connection
  • Humidifier Settings 1 - 5

Power Specifications

  • AC (Wall) Power 100-240V, 50-60Hz (Auto Sensing)
  • AC Power Supply Yes


Average Rating of
Total 8 Reviews
  • BiPap Pro

    I am completely satisfied with my Bipap Pro. Easy to operate, quiet, not too big and bulky. I am very happy so far. Thank you for the excellent service
    Written by Joe W, 2015-09-24
  • Hurrah for a good night's sleep

    When my insurance changed my home health provider took back my BiPap machine. After a few weeks, my sleep (or lack of sleep) was evident. Rather than go through insurance again, I searched for a way to buy a machine outright and found Direct Home had a great sale price on just the machine I wanted. My doctor was in agreement with the purchase and now I am sleeping again.
    Written by Linda B, 2015-06-26
  • Very Happy With Our Purchase

    Direct Home Medical is the best! We are very happy with this bipap purchase for my husband. The unit is very quiet and ends up being cheaper in the long run over monthly rental with Medicare's help. Saved us and the government some money.
    Written by Charles J, 2015-05-13
  • As good as the far more expensive newer 660 model

    Excellent bipap machine. I had a rental Philips Respironics 660 model; this prior 650 model if just as good and far less expensive.
    Written by Irwin, 2015-05-13
  • Excellent Service & Pricing

    I've been using this same machine for the last 5 years, and originally paid almost 2.5x the price their offered at now. While there are stores on the internet that will still sell the unit at the higher price, this store had an excellent deal. When my original 5 yr old machine began to fail, I called this store, and arranged to have a new machine shipped to me the next day. They committed to deliver, and made it happen. Packaging and machine set up was perfect. I'm using Directhomemedical for now on. thanks to their team!
    Written by DT in Fla, 2015-01-14
  • Very pleased

    I would like to say that I'm very impressed with your service and will be doing business again in the future. Any one that is skeptical of your services should not be. I asked how you could sell your systems at such a low price and your representatives were very knowledgeable and confident. You all put my mind at ease by dealing directly. Thank you again.
    Written by Richard B, 2013-07-17
  • Excellent BiPap

    My wife had to adjust to the fact this machine makes no noise other than the inhale/exhale! The humidifier works great. It's an excellent machine.
    Written by Bill, 2013-06-15
  • PR System One BiPAP PRO 650 Machine Package with Bi-Flex

    I received my new Bi-Pap machine promptly and I love it compared to my bulky old machine that was 7 yrs old. And, Direct Home Medical had the best price. I am very happy with this purchase.
    Written by Brian W., 2012-12-18