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The H2O Heated Humidifier works with most GoodKnight 420 Series CPAPs -- including the GoodKnight 420E, GoodKnight 420G, GoodKnight 420S and GoodKnight 420SP -- and GoodKnight 425 Series BiLevel Systems -- including the GoodKnight 425 and the GoodKnight 425 ST. The H2O water chamber is dishwasher safe for trouble-free maintenance.